Virological Features and Clinical Manifestations Associated with Human Metapneumovirus: A New Paramyxovirus Responsible for Acute Respiratory-Tract Infections in All Age Groups
Identifieur interne : 002F89 ( Main/Exploration ); précédent : 002F88; suivant : 002F90Virological Features and Clinical Manifestations Associated with Human Metapneumovirus: A New Paramyxovirus Responsible for Acute Respiratory-Tract Infections in All Age Groups
Auteurs : Guy Boivin [Canada] ; Yacine Abed [Canada] ; Gilles Pelletier [Canada] ; Louisette Ruel [Canada] ; Danielle Moisan [Canada] ; Stéphanie Côté [Canada] ; Teresa C. T. Peret [Géorgie (pays)] ; Dean D. Erdman [Géorgie (pays)] ; Larry J. Anderson [Géorgie (pays)]Source :
- The Journal of Infectious Diseases [ 0022-1899 ] ; 2002-11-01.
Abstract
The virological features and clinical findings associated with the new human metapneumovirus (HMPV) were examined retrospectively in Canadian patients hospitalized for various respiratory conditions since 1993. Thirty-eight previously unidentified respiratory viruses isolated from rhesus monkey kindey (LLC-MK2) cells were found to be positive for HMPV by reverse-transcription polymerase chain reaction, and those strains clustered in 2 phylogenetic groups. Children aged <5 years and elderly subjects aged >65 years represented 35.1% and 45.9% of the HMPV-infected cases, respectively. In hospitalized children, the most frequent diagnoses were pneumonitis (66.7%) and bronchiolitis (58.3%), whereas bronchitis and/or bronchospasm (60%) and pneumonitis (40%) were most commonly seen in elderly subjects. Of the 15 patients with pneumonitis, 4 (26.7%) had immunosuppressive conditions and 6 (40%) were infants aged <15 months. These findings suggest that HMPV can be associated with severe lower-respiratory-tract infections in very young children, the elderly, and immunocompromised patients
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DOI: 10.1086/344319
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Thirty-eight previously unidentified respiratory viruses isolated from rhesus monkey kindey (LLC-MK2) cells were found to be positive for HMPV by reverse-transcription polymerase chain reaction, and those strains clustered in 2 phylogenetic groups. Children aged <5 years and elderly subjects aged >65 years represented 35.1% and 45.9% of the HMPV-infected cases, respectively. In hospitalized children, the most frequent diagnoses were pneumonitis (66.7%) and bronchiolitis (58.3%), whereas bronchitis and/or bronchospasm (60%) and pneumonitis (40%) were most commonly seen in elderly subjects. Of the 15 patients with pneumonitis, 4 (26.7%) had immunosuppressive conditions and 6 (40%) were infants aged <15 months. These findings suggest that HMPV can be associated with severe lower-respiratory-tract infections in very young children, the elderly, and immunocompromised patients</div></front></TEI><affiliations><list><country><li>Canada</li><li>Géorgie (pays)</li></country></list><tree><country name="Canada"><noRegion><name sortKey="Boivin, Guy" sort="Boivin, Guy" uniqKey="Boivin G" first="Guy" last="Boivin">Guy Boivin</name></noRegion><name sortKey="Abed, Yacine" sort="Abed, Yacine" uniqKey="Abed Y" first="Yacine" last="Abed">Yacine Abed</name><name sortKey="Boivin, Guy" sort="Boivin, Guy" uniqKey="Boivin G" first="Guy" last="Boivin">Guy Boivin</name><name sortKey="Cote, Stephanie" sort="Cote, Stephanie" uniqKey="Cote S" first="Stéphanie" last="Côté">Stéphanie Côté</name><name sortKey="Moisan, Danielle" sort="Moisan, Danielle" uniqKey="Moisan D" first="Danielle" last="Moisan">Danielle Moisan</name><name sortKey="Pelletier, Gilles" sort="Pelletier, Gilles" uniqKey="Pelletier G" first="Gilles" last="Pelletier">Gilles Pelletier</name><name sortKey="Ruel, Louisette" sort="Ruel, Louisette" uniqKey="Ruel L" first="Louisette" last="Ruel">Louisette Ruel</name></country><country name="Géorgie (pays)"><noRegion><name sortKey="Peret, Teresa C T" sort="Peret, Teresa C T" uniqKey="Peret T" first="Teresa C. T." last="Peret">Teresa C. T. Peret</name></noRegion><name sortKey="Anderson, Larry J" sort="Anderson, Larry J" uniqKey="Anderson L" first="Larry J." last="Anderson">Larry J. Anderson</name><name sortKey="Erdman, Dean D" sort="Erdman, Dean D" uniqKey="Erdman D" first="Dean D." last="Erdman">Dean D. Erdman</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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